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Gene-expression analysis after alcohol exposure in the developing mouse.

Marjie L Hard1, Mohamed Abdolell, Brian H Robinson

  • 1The Hospital for Sick Children, the Department of Pharmaceutical Sciences, University of Toronto, Ontario M5G 1X8, Canada.

The Journal of Laboratory and Clinical Medicine
|January 26, 2005
PubMed
Summary

Prenatal alcohol exposure down-regulates 25 genes in the fetal mouse brain, impacting cell growth and survival. These findings may help identify genetic markers for fetal alcohol syndrome.

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Area of Science:

  • Developmental Biology
  • Neuroscience
  • Genetics

Background:

  • Embryonic exposure to alcohol can cause significant structural and neurophysiologic changes in developing fetuses.
  • The precise mechanisms underlying these alcohol-induced developmental alterations remain largely unknown.

Purpose of the Study:

  • To investigate ethanol-induced changes in gene expression within the fetal brain.
  • To identify specific genes affected by prenatal alcohol exposure and explore their roles.

Main Methods:

  • Utilized complementary-DNA (cDNA) microarrays to analyze gene expression profiles.
  • Examined gene expression on days 7 and 9 of gestation in mouse embryos exposed to ethanol.

Main Results:

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  • Identified 25 genes that were significantly down-regulated by prenatal ethanol exposure.
  • No genes were found to be up-regulated by the exposure.
  • Six specific down-regulated genes (Timp4, Bmp15, Rnf25, Akt1, Tulp4, Dexras1) were identified and discussed.

    • Conclusions:

    • The identified down-regulated genes are involved in critical fetal development processes, including cell proliferation, differentiation, apoptosis, tissue growth, and neuronal survival.
    • Microarray analysis shows promise for identifying genetic markers associated with fetal alcohol syndrome.
    • This research may uncover novel pathways contributing to the origins of fetal alcohol syndrome.