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The association of body mass index and prostate-specific antigen in a population-based study
Jacques Baillargeon1, Brad H Pollock, Alan R Kristal
1Center for Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, Texas 78284-7802, USA. baillargeon@uthscsa.edu
Background:
Recent studies of men with prostate carcinoma suggest that obesity may be associated with more advanced-stage disease and lower overall survival rates. One possible link between body mass index (BMI) and prostate carcinoma prognosis may be disease ascertainment. Prostate-specific antigen (PSA) is widely used to screen for prostate carcinoma.
Methods:
The authors examined the association between BMI and PSA in a population-based study of 2779 men without prostate carcinoma. Between 2001 and 2004, these men were enrolled in a study sponsored by the San Antonio Center of Biomarkers of Risk, a clinical and epidemiologic center of the Early Detection Research Network of the National Cancer Institute.
Results:
The mean PSA value decreased in a linear fashion with an increase in BMI category, from 1.01 ng/mL in normal weight men to 0.69 ng/mL in obese (Class III) men, after adjusting for race/ethnicity and age.
Conclusions:
Lower levels of PSA in obese and overweight men could mask biologically consequential prostate carcinoma.
