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Evidence-based disease management: its role in cardiovascular risk reduction
1Sanofi-Synthelabo, San Antonio, Texas 78232, USA. Etta.Fanning@us.sanofi.com
Insights
Cardiovascular disease is a major US health issue, driven by traditional and emerging risk factors like obesity and diabetes. Addressing these requires a comprehensive public health approach for effective disease management and prevention.
Area of Science:
- Public Health
- Cardiology
- Epidemiology
Background:
- Cardiovascular disease (CVD) is a leading US health concern.
- Unresolved traditional risk factors (hypertension, obesity, diabetes) persist.
- Emerging factors include pre-diabetes, insulin resistance, and pediatric/adolescent diabetes.
Purpose of the Study:
- Review the burden of cardiovascular illness (morbidity, mortality, cost).
- Examine risk factors, including the adolescent obesity epidemic.
- Discuss challenges in achieving treatment goals.
- Identify attributes of successful healthcare initiatives for CVD.
Main Methods:
- Literature review of cardiovascular disease burden and risk factors.
- Analysis of emerging trends in obesity and diabetes.
- Qualitative and quantitative approaches for evidence development.
Main Results:
- Significant morbidity, mortality, and economic costs associated with CVD.
- Rising prevalence of obesity and diabetes in adolescents.
- Challenges exist in meeting therapeutic targets for CVD risk factors.
Conclusions:
- Urgent need for identifying CVD risk factors.
- Risk reduction strategies require integrated disease management and treatment.
- Successful public health initiatives are crucial for improving cardiovascular care.
Abstract:
Cardiovascular disease remains the most pressing healthcare problem in the United States. Traditional risk factors--hypertension, obesity, and diabetes-are still unresolved issues; and new risk factors--pre-diabetes, insulin resistance, and pediatric and adolescent diabetes-have emerged. There is an urgent need to identify the risk factors for cardiovascular disease, and address risk reduction with disease management and treatment for each factor, based on qualitative and quantitative approaches for developing the evidence base for public health action. The objectives of this paper are to review (i) the burden of cardiovascular illness-morbidity, mortality, and cost; (ii) risk factors and the emerging epidemic of adolescent obesity; (iii) the challenges of attaining target endpoints; and (iv) the attributes of a successful programmatic healthcare initiative for potential impact on cardiovascular care and, eventually, public health.
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