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Cubic phases and cubic phase dispersions in a phospholipid-based system
Markus Johnsson1, Justas Barauskas, Fredrik Tiberg
1Camurus AB, Ideon, Gamma 2, Sölvegatan 41, SE-223 70, Lund, Sweden, and Physical Chemistry 1, Center for Chemistry and Chemical Engineering, Lund University, PO Box 124, SE-221 00 Lund, Sweden. markus.johnsson@camurus.ideon.se
Journal of the American Chemical Society
|January 27, 2005
Summary
This study characterizes a cubic liquid crystalline phase system using dioleoylphosphatidylethanolamine (DOPE) and PEGylated glycerol monooleate (PEG(660)-GMO). The system forms colloidal particles with a stable cubic phase structure, even in dilute conditions.
Area of Science:
- Materials Science
- Biophysics
- Physical Chemistry
Background:
- Phospholipid-based liquid crystalline phases are crucial in various applications.
- Dioleoylphosphatidylethanolamine (DOPE) is a common phospholipid for forming such phases.
- Stabilizing these phases, especially in colloidal forms, remains a challenge.
Purpose of the Study:
- To characterize a novel cubic liquid crystalline phase system.
- To investigate the effect of PEGylated glycerol monooleate (PEG(660)-GMO) on DOPE-based cubic phases.
- To explore the formation of colloidal particles from this system.
Main Methods:
- System preparation using DOPE, PEG(660)-GMO, and water.
- Phase behavior analysis across different concentrations.
- Characterization of the cubic phase structure and particle formation.
Main Results:
- A stable cubic liquid crystalline phase was formed by the DOPE/PEG(660)-GMO/water system.
- The cubic phase coexists with water in dilute regions of the phase diagram.
- The system can be fragmented into colloidal particles that retain the cubic phase structure.
Conclusions:
- The addition of PEG(660)-GMO stabilizes the DOPE-based cubic liquid crystalline phase.
- This system offers a method for creating stable, cubic phase nanoparticles.
- Potential applications in drug delivery and materials science are suggested.
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