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Updated: Aug 19, 2026

Electrocardiogram Recordings in Anesthetized Mice using Lead II
Published on: June 20, 2020
Heart rate influences on repolarization duration and morphology in symptomatic versus asymptomatic KCNQ1 mutation
Fabrice Extramiana1, Isabelle Denjoy, Fabio Badilini
1Service de Cardiologie, Groupe Hospitalier Lariboisière, Paris, France. fabrice.extramiana@lrb.ap-hop-paris.fr
Abstract:
QT and Tp/Te intervals were longer in patients with LQT1 (n = 67) than in nonaffected subjects (n = 52) but did not differentiate symptomatic (n = 21) from asymptomatic patients (n = 46). At fast heart rate, the time to accumulate the last part of total T-wave area (the t50-97 interval) was longer in symptomatic carriers compared with asymptomatic patients (119 +/- 19 vs 106 +/- 15 ms, p <0.01). The latter group had significantly longer t50-97 intervals than nonaffected subjects (96 +/- 14 ms, p <0.01).
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