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Cytosporone E: racemic synthesis and preliminary antibacterial testing
Jeffrey D Hall1, Nathan W Duncan-Gould, Nasar A Siddiqi
1Department of Chemistry and Biochemistry, College of Charleston, 66 George Street, Charleston, SC 29424, USA.
Bioorganic & Medicinal Chemistry
|January 27, 2005
Abstract:
The antibiotic cytosporone E (isolated from the broth of the endophytic fungi CR 200 (Cytospora sp.) and CR 146 (Diaporthe sp.)) was synthesized as a racemic mixture. The key step in the synthesis is the Meyers ortho-alkylation of a chiral aromatic oxazoline. Preliminary antibiotic activity shows antibiosis against Gram-positive bacteria but not Gram-negative bacteria as previously reported.