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Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation
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"Benign" course and malignant clinical presentations of congenital long QT syndrome

Vladimir Khalameizer1, Nadia Pancheva, Leonardo Reizin

  • 1Barzilai Medical Center, Ashkelon & Faculty of Health Sciences, Ben Gurion University of the Negev, BeerSheva, Israel.

Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology
|January 27, 2005
PubMed

This report describes the "benign" clinical course of a congenital long QT syndrome (LQTS) simulated acute coronary event in an 85 year old woman who had a history of recurrent syncope accompanied by numerous severe traumatic events from childhood. Her daughter died suddenly. LQTS was diagnosed on the basis of characteristic ECG findings, including a permanently prolonged QT interval, typical dynamic T-wave changes, and runs of torsades de pointes. A permanent DDDR pacemaker was implanted. Eighteen months after implantation there have been no further complaints of dizziness or syncope.

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