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Cardiac functional analysis with multi-detector row CT and segmental reconstruction algorithm: comparison with
Masaki Yamamuro1, Eiji Tadamura, Shigeto Kubo
1Department of Nuclear Medicine and Diagnostic Imaging, Kyoto University Graduate School of Medicine, 54 Shogoinkawahara, Sakyo-ku, Kyoto 606-8507, Japan. myamamu@kuhp.kyoto-u.ac.jp
Radiology
|January 27, 2005
Summary
Multi-detector row computed tomography (CT) provides accurate cardiac functional analysis, correlating well with magnetic resonance (MR) imaging. This CT method offers superior accuracy compared to echocardiography and SPECT for evaluating left ventricular (LV) parameters.
Area of Science:
- Cardiovascular Imaging
- Radiology
- Medical Physics
Background:
- Accurate assessment of cardiac function is crucial for diagnosing and managing cardiovascular diseases.
- Multi-detector row computed tomography (CT) is increasingly used for cardiac imaging, but its accuracy for functional analysis needs thorough evaluation.
- Magnetic resonance (MR) imaging is considered a reference standard for cardiac function assessment.
Purpose of the Study:
- To evaluate the accuracy of cardiac functional analysis using multi-detector row CT with a segmental reconstruction algorithm.
- To compare the accuracy of multi-detector row CT for estimating left ventricular (LV) functional parameters against MR imaging, echocardiography, and SPECT.
- To assess the performance of multi-detector row CT across a range of heart rates.
Main Methods:
- Fifty patients underwent multi-detector row CT and MR imaging. Two-dimensional echocardiography and ECG-gated SPECT were performed in subsets of patients.
- End-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction (EF), and LV mass were calculated using multi-detector row CT and compared with MR imaging reference values.
- Systemic error and agreement were assessed, with linear regression analysis employed in a secondary analysis.
Main Results:
- Multi-detector row CT demonstrated excellent agreement and correlation with MR imaging for EF (r = 0.96), EDV (r = 0.97), ESV (r = 0.99), and LV mass (r = 0.96).
- The standard deviation of EF differences was significantly smaller between multi-detector row CT and MR imaging compared to echocardiography-MR (P < .001) and SPECT-MR (P < .001).
- The segmental approach with multi-detector row CT yielded accurate measurements of LV functional parameters.
Conclusions:
- Multi-detector row CT, utilizing a segmental reconstruction algorithm, accurately measures various LV functional parameters.
- The accuracy of multi-detector row CT for cardiac functional analysis is comparable to MR imaging.
- Multi-detector row CT provides more accurate functional analysis than two-dimensional echocardiography or ECG-gated SPECT.