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Related Experiment Videos

Clinically silent somatotropinomas may be biochemically active.

Alla A Sakharova1, Eleni V Dimaraki, William F Chandler

  • 1University of Michigan Medical Center, 3920 Taubman Center, Box 0354, Ann Arbor, Michigan 48109, USA.

The Journal of Clinical Endocrinology and Metabolism
|January 27, 2005
PubMed
Summary

Pituitary tumors can secrete growth hormone (GH) without causing acromegaly symptoms. Early evaluation for GH excess is recommended for patients with pituitary tumors, particularly younger women.

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Pituitary·2020

Area of Science:

  • Endocrinology
  • Oncology
  • Neuroscience

Background:

  • Acromegaly diagnosis typically relies on clinical signs and elevated insulin-like growth factor-I (IGF-I) and growth hormone (GH) levels.
  • Pituitary tumors are a common cause of acromegaly.

Observation:

  • Three female patients with pituitary tumors presented with elevated IGF-I but no acromegaly symptoms.
  • Dynamic testing revealed elevated mean, trough, and post-glucose GH levels in all patients.
  • Magnetic resonance imaging confirmed pituitary tumors, and surgery revealed GH-producing adenomas.

Findings:

  • Elevated GH and IGF-I levels can occur in pituitary tumors without overt acromegaly.
  • Two of three patients normalized IGF-I levels after surgical tumor removal.
  • GH-producing pituitary adenomas may not exhibit typical clinical features of acromegaly.

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Implications:

  • Suggests a need for biochemical evaluation of GH excess in patients with pituitary tumors, especially in younger women with normal or mildly elevated prolactin.
  • Highlights that pituitary adenomas can be GH-secreting without classic acromegaly stigmata.
  • Underscores the importance of considering subclinical GH excess in specific patient populations.