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Published on: November 20, 2018
Characterization of a centromeric marker on mouse chromosome 11 and its introgression in a domesticus/musculus hybrid
Isabelle Lanneluc1, Erick Desmarais, Pierre Boursot
1Laboratoire Genome Populations Interactions Adaptation (UMR 5171 CNRS-UM2-IFREMER), Université de Montpellier II C.C. 63, Place E. Bataillon, 34095 Montpellier 5, France.
Abstract:
It has been proposed that the distribution of Robertsonian chromosome fusions and the Chromosome 11 Nucleolar Organizer Region (NOR) in the Danish hybrid zone between M. m. musculus and M. m. domesticus stems from centromeric incompatibilities between the two subspecies. To test this hypothesis, we identified and characterized a diagnostic subspecific marker closely linked to the centromere on mouse Chromosome 11. Using an allele-specific PCR assay, we investigated the introgression pattern of this centromere in a large sample of mice from a North-South transect of the hybrid zone in Jutland. Domesticus alleles were found to introgress far away from the center of the zone on the musculus side. These results suggest there is no incompatibility between the domesticus centromere of Chromosome 11 in the musculus genomic background.
