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High plasma concentrations of osteopontin in patients with interstitial pneumonia

J Kadota1, S Mizunoe, K Mito

  • 1Division of Pathogenesis and Disease Control, Department of Infectious Diseases, Faculty of Medicine, Oita University, 1-1 Hasama, Oita 879-5593, Japan. kadota@med.oita-u.ac.jp

Respiratory Medicine
|January 28, 2005
PubMed

Insights

Plasma osteopontin (OPN) levels are elevated in interstitial pneumonia (IP) patients, correlating with disease severity. This suggests OPN may be a key biomarker and factor in IP development.

Area of Science:

  • Pulmonary Medicine
  • Immunology
  • Biomarker Discovery

Background:

  • Osteopontin (OPN) is implicated as a fibrogenic cytokine in bleomycin-induced pulmonary fibrosis.
  • OPN mRNA is detected in lung tissues of idiopathic pulmonary fibrosis (IPF) patients.
  • The role of plasma OPN levels in human interstitial pneumonia (IP) requires further investigation.

Purpose of the Study:

  • To investigate plasma osteopontin (OPN) levels in patients with interstitial pneumonia (IP).
  • To assess the relationship between plasma OPN concentrations and disease severity in IP.
  • To analyze the correlation between plasma OPN levels and pulmonary function parameters.

Main Methods:

  • Plasma OPN concentrations were measured using an antigen-capture enzyme-linked immunosorbent assay (ELISA).
  • Measurements were performed in 17 IP patients, 9 sarcoidosis patients, and 20 healthy controls.
  • Receiver Operating Characteristic (ROC) curve analysis was used to determine diagnostic cut-off points.

Main Results:

  • Plasma OPN levels were significantly higher in IP patients compared to sarcoidosis patients and healthy controls.
  • ROC analysis identified cut-off points (300-380 ng/ml) with 100% sensitivity and specificity for distinguishing IP from controls.
  • Plasma OPN levels showed an inverse correlation with arterial oxygen tension (PaO2) in IP patients.

Conclusions:

  • Elevated plasma osteopontin (OPN) levels are associated with the presence of interstitial pneumonia (IP).
  • OPN may play a significant role in the pathogenesis and development of IP.
  • Plasma OPN shows potential as a diagnostic biomarker for IP, correlating with disease severity.

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