Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Non-antigen specific CD8+ T suppressor lymphocytes.

G Filaci1, M Fravega, D Fenoglio

  • 1Department of Internal Medicine (DIMI) and Centre of Excellence for Biomedical Research (CEBR), University of Genoa, Viale Benedetto XV n.b., I-16132 Genoa, Italy. gfilaci@unige.it

Clinical and Experimental Medicine
|January 28, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Ethical Principles in Legal Context: Vaccine Mandates During the COVID-19 Pandemic in Australia.

Journal of bioethical inquiry·2026
Same author

Harnessing Platelet-derived factors to reactivate Nucleus Pulposus cells in Intervertebral Disc Regeneration.

Regenerative therapy·2026
Same author

Endothelial CHOP as a central mechanism in renovascular hypertension-induced vascular endothelial dysfunction and cardiac fibrosis.

Cellular and molecular life sciences : CMLS·2025
Same author

Anti-myeloperoxidase IgM B cells in anti-neutrophil cytoplasmic antibody-associated vasculitis.

Nature communications·2025
Same author

A simple cell proliferation assay and the inflammatory protein content show significant differences in human plasmas from young and old subjects.

Frontiers in bioengineering and biotechnology·2024
Same author

Author Correction: Restoration of vision after transplantation of photoreceptors.

Nature·2024

Regulatory CD8+ T suppressor lymphocytes, which function without antigen restriction, are crucial for immune homeostasis. Their impairment is linked to autoimmune diseases, cancer immunosuppression, and HIV immunodeficiency.

Area of Science:

  • Immunology
  • Cellular Biology

Background:

  • Peripheral immune system homeostasis relies on regulatory lymphocytes.
  • A subset of CD8+CD28- T suppressor lymphocytes mediates effects without antigen restriction.
  • These cells originate from circulating CD8+CD28- T cells upon stimulation with interleukin-2 and interleukin-10.

Purpose of the Study:

  • To characterize the function and role of non-antigen-specific CD8+ T suppressor lymphocytes.
  • To investigate the involvement of CD8+ suppressor cells in autoimmune diseases, cancer, and HIV infection.

Main Methods:

  • Characterization of CD8+CD28- T suppressor lymphocytes.
  • Analysis of cytokine secretion (interferon-gamma, interleukin-6, interleukin-10).
  • Assessment of CD8+ suppressor cell function in patients with autoimmune diseases, cancer, and HIV.

Related Experiment Videos

Main Results:

  • CD8+ suppressor cells inhibit CD4+ T cell proliferation and cytotoxicity via cytokine secretion.
  • Impaired CD8+ suppressor cell function is observed in systemic lupus erythematosus and systemic sclerosis.
  • CD8+ suppressor cells are found in tumors, potentially contributing to immunosuppression.
  • Reduced generation of CD8+ suppressor cells is noted in HIV-infected patients.

Conclusions:

  • CD8+ T suppressor cells play a significant role in immune regulation.
  • Dysfunction or absence of these cells is implicated in the pathogenesis of autoimmune diseases, cancer immune evasion, and HIV-induced immunodeficiency.
  • Further research is needed to elucidate the precise mechanisms behind CD8+ suppressor cell impairment in HIV infection.