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Effects of chronic variable stress and antidepressant drugs on behavioral inactivity during an uncontrollable stress:
1Escuela de Psicologia, Facultad de Filosofia y Humanidades, Universidad Nacional de Cordoba, Argentina.
Behavioral and Neural Biology
|January 1, 1992
Abstract:
Rats submitted to a chronic variable stress regime exhibited more inactivity during inescapable shock as compared with unstressed rats. Besides, chronic treatments with desipramine, imipramine, clomipramine, or phenelzine reduce the amount of inactivity exhibited during this aversive experience. Furthermore, the combination of both chronic treatments--stress and antidepressants--resulted in a potentiation of the antidepressant effect alone. This higher antidepressant efficacy may result from the interaction of the neural mechanisms triggered by chronic stress exposure and antidepressant drugs.