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Updated: Aug 19, 2026
Cell-Free DNA Integrity Analysis in Urine Samples
Published on: January 5, 2017
Detection of urine survivin in 40 patients with bladder cancer
Ikuroh Ohsawa1, Taiji Nishimura, Yukihiro Kondo
1Department of Biochemistry and Cell Biology, Institute of Development and Aging Sciences, Graduate School of Medicine, Nippon Medical School, Tokyo 113-8603, Japan.
Purpose:
We investigated whether urine survivin, an inhibitor of the apoptosis protein, is useful for diagnosing bladder tumor.
Method:
We measured urine survivin levels in 40 patients with bladder tumors and 9 healthy volunteers.
Results:
The average urine survivin levels in the 40 patients and 9 healthy controls were not significantly different (3.802+/-8.669 and 1.127+/-1.529, respectively (p=0.3646) ). However, significantly high urine survivin levels were observed in 3 of the 40 patients, but not in healthy volunteers. Urine Cyfra 21-1 was not elevated (1.3 ng/ml) in one patient with a significantly elevated urine survivin level (33.54 ng/ml), while in two patients with elevated Cyfra (320 ng/ml and 240 ng/ml), the urine survivin level was not detectable.
Conclusion:
With improvements in the sensitivity of our Elisa system for urine survivin and combined use of urine Cyfra 21-1, it is possible that urine survivin will be a useful tumor marker in detecting both new-onset and recurrent bladder tumors.
