Cisplatin-induced imbalances in the pattern of chimeric marker gene expression in HeLa cells

The effects of the antitumor drug cisplatin on gene expression have been measured during transient transfections in HeLa cells. The results indicate a surprising diversity of response. Expression from two promoters is strongly induced, both in non-replicating plasmids and cellular integrants, whereas expression from two other promoters is strongly inhibited. The results suggest that a drug-induced imbalance in gene expression may contribute to the antitumor properties of cisplatin.