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Published on: June 15, 2019

Drug susceptibility of isolates from severe postoperative intraperitoneal infections causing multiple organ failure

Shinya Kusachi1, Yoshinobu Sumiyama, Jiro Nagao

  • 1Third Department of Surgery, Toho University, School of Medicine, 2-17-6 Ohashi, Meguro-ku, Tokyo 153-8515, Japan.

Surgery Today
|January 28, 2005
PubMed
Abstract

Insights

Vancomycin (VCM) and Teicoplanin (TEIC) are effective against Methicillin-resistant Staphylococcus aureus (MRSA) infections. Meropenem (MEPM), Ceftazidime (CAZ), Ciprofloxacin (CPFX), and Pazufloxacin (PZFX) show efficacy against Pseudomonas aeruginosa, while Imipenem (IPM) is effective for Bacteroides fragilis.

Area of Science:

  • Infectious Diseases
  • Clinical Microbiology
  • Pharmacology

Background:

  • Postoperative infections pose a significant threat, often leading to multiple organ failure (MOF).
  • Selecting appropriate antibiotic regimens is critical for managing severe postoperative infections.

Purpose of the Study:

  • To determine optimal antibiotic choices for life-threatening postoperative infections.
  • To analyze drug susceptibility patterns of bacterial isolates from severe infections.

Main Methods:

  • Retrospective analysis of bacterial isolates from 55 patients with MOF due to postoperative infection over 12 years.
  • Evaluation of antibiotic susceptibility testing for various bacterial pathogens.

Main Results:

  • Methicillin-resistant Staphylococcus aureus (MRSA) strains were fully susceptible to Vancomycin (VCM) and Teicoplanin (TEIC).
  • Pseudomonas aeruginosa showed high resistance to Imipenem (IPM) (53.6% in severe infections) but remained susceptible to Meropenem (MEPM), Ceftazidime (CAZ), Ciprofloxacin (CPFX), and Pazufloxacin (PZFX).
  • Bacteroides fragilis exhibited 35.9% resistance to Clindamycin (CLDM), with some resistance to IPM and Panipenem.

Conclusions:

  • Vancomycin (VCM) or Teicoplanin (TEIC) are recommended for MRSA-induced severe abdominal abscesses.
  • Meropenem (MEPM), Ceftazidime (CAZ), Ciprofloxacin (CPFX), and Pazufloxacin (PZFX) are effective choices for Pseudomonas aeruginosa infections.
  • Imipenem (IPM) was the only effective antibiotic against Bacteroides fragilis in this study.

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