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Updated: Aug 19, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
NMR investigation into the dynamic behaviour of a novel C2-symmetric macrocyclic ligand
J Erik W Scheuermann1, Edson S Bento, Geoffrey E Hawkes
1Department of Chemistry, Queen Mary, University of London, Mile End Road, London E1 4NS, UK.
Abstract:
The variable-temperature (1)H NMR spectra of a tosylated triazacyclononane are reported. The spectra show a dynamic process which is assigned to hindered rotation about the amide-like N--S bonds, and a value for the free energy of activation for the rotations is derived, DeltaG* = 50.2 kJ mol(-1) at 273 K. Steric and electronic factors which influence the barrier are discussed.
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