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Related Experiment Videos

Dynamic expression pattern of Hoxc8 during mouse early embryogenesis.

Yunjeong Kwon1, Jaeseung Shin, Hyoung Woo Park

  • 1Department of Anatomy, Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, South Korea.

The Anatomical Record. Part A, Discoveries in Molecular, Cellular, and Evolutionary Biology
|January 28, 2005
PubMed
Summary

Hoxc8 gene expression in mouse embryos reveals its role in neural and mesodermal development. This study tracks Hoxc8 patterns from 7.5 to 12.5 days postcoitum, highlighting its involvement in forming vertebrae, ribs, and kidneys.

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Area of Science:

  • Developmental Biology
  • Molecular Biology
  • Genetics

Background:

  • The Hoxc8 gene is a key developmental regulator.
  • Understanding its spatiotemporal expression is crucial for deciphering embryonic development.

Purpose of the Study:

  • To investigate the expression pattern of the Hoxc8 gene in mouse embryos.
  • To correlate Hoxc8 expression with specific developmental processes.

Main Methods:

  • Whole-mount in situ hybridization.
  • Reverse transcription polymerase chain reaction (RT-PCR).
  • Analysis of mouse embryos from 7.5 to 12.5 days postcoitum.

Main Results:

  • Hoxc8 expression initiates between 7.5 and 8.5 days postcoitum.

Related Experiment Videos

  • Distinct anterior boundaries of Hoxc8 expression were established in neural tube and paraxial mesoderm.
  • Expression patterns suggest roles in neural differentiation, vertebral/rib formation, and kidney development.

    • Conclusions:

    • Hoxc8 expression is dynamic and spatially regulated during mouse embryogenesis.
    • Hoxc8 plays a significant role in the development of the central nervous system and axial skeleton.
    • The gene is implicated in mesonephros and kidney formation.