Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Treatment for Pulmonary Arterial Hypertension: Oxygen Therapy for Respiratory Failure

Oxygen therapy has emerged as a significant tool in enhancing the quality of life for patients suffering from pulmonary arterial hypertension (PAH). While this therapy has principally been studied on patients with significant hypoxemia, this therapeutic approach helps prevent potential organ damage and can be administered in the comfort of one's home.
Oxygen therapy is vital in increasing and maintaining blood oxygen levels in PAH patients. As a result, it aids in reducing fatigue, improving...

Oxygen Transport in the Blood

Oxygen Transport in the Blood

Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...

Hypoxia

Hypoxia

Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...

Chemical Factors Affecting Respiration Centers

Chemical Factors Affecting Respiration Centers

Chemical factors such as changing CO2, O2, and H+ levels in arterial blood play a critical role in influencing respiration depth and rates. These variations are detected by chemoreceptors—specialized sensors located in two primary body areas. Central chemoreceptors are found throughout the brain stem, including the ventrolateral medulla, while peripheral chemoreceptors are located in the aortic arch and carotid arteries.
CO2 has a potent influence on respiration and is strictly regulated. Under...

Hyperpnea and Hyperventilation

Hyperpnea and Hyperventilation

Hyperventilation refers to a higher-than-normal rate and depth of breathing, often associated with anxiety attacks. This excessive breathing surpasses the body's need to expel CO2, leading to a condition known as hypocapnia - an unusually low level of carbon dioxide in the blood. Hypocapnia can constrict cerebral blood vessels, reducing blood flow to the brain, which may result in dizziness or fainting. Early signs include tingling and muscle spasms in the hands and face, caused by falling...

Acute Respiratory Failure-III

Acute Respiratory Failure-III

Hypercapnic respiratory failure, also known as Type 2 or ventilatory respiratory failure, is a severe condition characterized by the body's inability to effectively remove carbon dioxide (CO2) from the bloodstream. It leads to an arterial CO2 pressure (PaCO2) exceeding 45 mmHg and a blood pH above 7.35. This situation indicates that the body's ventilatory demand, or the ventilation needed to maintain normal PaCO2 levels, surpasses its supply or the maximum gas flow achievable without causing...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Milestones in the natural course of the onset of e-cigarette dependence among adolescents and young adults: Retrospective study.

Addictive behaviors·2023

Same author

Activated Charcoal and Bicarbonate for Aspirin Toxicity: a Retrospective Series.

Journal of medical toxicology : official journal of the American College of Medical Toxicology·2021

Same author

Circumcision and Risk of HIV among Males from Ontario, Canada. Reply.

The Journal of urology·2021

Same author

Over half of seniors who start oral bisphosphonate therapy are exposed for 3 or more years: novel rolling window approach and patterns of use.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2021

Same author

Life-threatening triclopyr poisoning due to diethylene glycol monoethyl ether solvent.

Clinical toxicology (Philadelphia, Pa.)·2020

Same author

A randomized controlled trial of fresh frozen plasma for coagulopathy in Russell's viper (Daboia russelii) envenoming.

Journal of thrombosis and haemostasis : JTH·2017

Search research articles

Related Experiment Video

Updated: Jul 22, 2026

Expired CO2 Measurement in Intubated or Spontaneously Breathing Patients from the Emergency Department

Expired CO₂ Measurement in Intubated or Spontaneously Breathing Patients from the Emergency Department

Published on: January 29, 2011

Hyperbaric oxygen for carbon monoxide poisoning.

D N Juurlink¹, N A Buckley, M B Stanbrook

¹Institute for Clinical Evaluative Sciences G-106, Sunnybrook and Women's College Health Sciences centre, 2075 Bayview Avenue, Toronto, Ontario, Canada, M4N 3M5. david.juurlink@ices.on.ca

The Cochrane Database of Systematic Reviews

|January 28, 2005

Summary

Hyperbaric oxygen (HBO) therapy for carbon monoxide (CO) poisoning does not show a clear benefit in preventing neurological sequelae based on current randomized trials. More research is needed to determine HBO's role in CO poisoning treatment.

More Related Videos

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Published on: May 4, 2021

Related Experiment Videos

Last Updated: Jul 22, 2026

Expired CO2 Measurement in Intubated or Spontaneously Breathing Patients from the Emergency Department

Expired CO₂ Measurement in Intubated or Spontaneously Breathing Patients from the Emergency Department

Published on: January 29, 2011

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Retinal Vascular Reactivity as Assessed by Optical Coherence Tomography Angiography

Published on: March 26, 2020

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

A Novel Inhalation Mask System to Deliver High Concentrations of Nitric Oxide Gas in Spontaneously Breathing Subjects

Published on: May 4, 2021

Area of Science:

Emergency Medicine
Toxicology
Hyperbaric Medicine

Background:

Carbon monoxide (CO) poisoning is a significant global health concern.
Previous studies suggested hyperbaric oxygen (HBO) may prevent neurological issues.
HBO is widely used for CO poisoning despite limited high-quality evidence.

Purpose of the Study:

To evaluate the effectiveness of HBO versus normobaric oxygen (NBO) in preventing neurological sequelae after acute CO poisoning.
To analyze data from randomized controlled trials (RCTs).

Main Methods:

Searched MEDLINE, EMBASE, and Cochrane Trials Register.
Included RCTs of non-pregnant adults with acute CO poisoning.
Two reviewers extracted data on participants, interventions, and outcomes.

Main Results:

Six RCTs of varying quality were analyzed.
Four trials found no benefit of HBO; two suggested a benefit.
Pooled analysis showed no significant benefit (OR 0.78, 95%CI 0.54-1.12), with considerable heterogeneity and methodological flaws.

Conclusions:

Current RCTs do not confirm HBO's efficacy in reducing neurological sequelae in CO poisoning.
Further high-quality, multi-center RCTs are necessary to clarify HBO's role.
The optimal treatment strategy for CO poisoning requires additional investigation.