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Arthritis and hypertension in patients with systemic lupus erythematosus
D Kaplan1, E M Ginzler, J Feldman
1Department of Medicine, State University of New York Health Science Center, Brooklyn 11203.
Objective:
The purpose of this study was to test the hypothesis that patients with systemic lupus erythematosus (SLE) who have, as part of their disease, persistent rheumatoid-like arthritis are less likely to be hypertensive than are other patients with SLE.
Methods:
A retrospective chart analysis of 662 patients with SLE seen in a university clinic was performed.
Results:
Data analysis revealed that hypertension and persistent arthritis were inversely correlated, particularly in those patients without nephritis and particularly in black patients.
Conclusion:
We conclude that rheumatoid-like arthritis in patients with SLE is protective against hypertension, and speculate that this protection is conferred by a higher frequency of the DR4 allele.
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