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Published on: February 5, 2019
Interventions for infantile esotropia
1Ophthalmology Department, Salisbury Health Care NHS Trust, Salisbury District Hospital, Salisbury, Wiltshire, UK, SP2 8BJ. sue.elliott@salisbury.nhs.uk
Insights
This review found no studies on infantile esotropia interventions, highlighting a critical need for high-quality trials. Current evidence is insufficient to guide treatment decisions for this condition.
Area of Science:
- Ophthalmology
- Pediatric Ophthalmology
- Strabismus Management
Background:
- Clinical management of infantile esotropia (IE) lacks clarity regarding optimal interventions and timing.
- Uncertainty exists on the most effective surgical and non-surgical treatment approaches for IE.
- The ideal age for initiating treatment for infantile esotropia remains a significant question.
Purpose of the Study:
- To evaluate the efficacy of diverse surgical and non-surgical interventions for infantile esotropia.
- To determine the impact of treatment age on outcomes in infantile esotropia management.
- To synthesize existing evidence on infantile esotropia treatment effectiveness.
Main Methods:
- Systematic review of randomized controlled trials (RCTs) for infantile esotropia interventions.
- Comprehensive literature search including Cochrane CENTRAL, MEDLINE, EMBASE, LILACS, and conference proceedings.
- Manual searches and direct contact with researchers to identify all relevant published and unpublished studies.
Main Results:
- No randomized controlled trials met the selection criteria for this review.
- The review could not identify any studies suitable for analysis regarding infantile esotropia interventions.
- Consequently, no data was available to assess the effectiveness of different treatments or the significance of intervention age.
Conclusions:
- Existing literature on infantile esotropia interventions primarily consists of retrospective and prospective cohort studies.
- This review could not resolve controversies surrounding the type of surgery, non-surgical options, or optimal age for intervention in IE.
- There is an urgent need for high-quality randomized trials to establish a robust evidence base for managing infantile esotropia.
Background:
Various aspects of the clinical management of infantile esotropia (IE) are unclear - mainly, the most effective type of intervention and the age at intervention.
Objectives:
The objective of this review was to assess the effectiveness of various surgical and non-surgical interventions for IE and to determine the significance of age at treatment with respect to outcome.
Search Strategy:
Trials were identified from the Cochrane Central Register of Controlled Trials - CENTRAL (which contains the Cochrane Eyes and Vision Group Trials Register) in The Cochrane Library (Issue 3 2004), MEDLINE (1966 to July 2004), EMBASE (1980 to August 2004) and LILACS (July 2004). We manually searched the conference proceedings of the European Strabismological Association (ESA) (1975-1997, 1999-2002), International Strabismological Association (ISA) (1994) and American Academy of Paediatric Ophthalmology and Strabismus meeting (AAPOS) (1995-2003). Efforts were made to contact researchers who are active in the field for information about further published or unpublished studies.
Selection Criteria:
Randomised trials comparing any surgical or non-surgical intervention for infantile esotropia.
Data Collection And Analysis:
Each reviewer independently assessed study abstracts identified from the electronic and manual searches.
Main Results:
No studies were found that met our selection criteria and therefore none were included for analysis.
Authors' Conclusions:
The main body of literature on interventions for IE are either retrospective studies or prospective cohort studies. It has not been possible through this review to resolve the controversies regarding type of surgery, non-surgical intervention and age of intervention. There is clearly a need for good quality trials to be conducted in these areas to improve the evidence base for the management of IE.
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