Related Experiment Video
Updated: Aug 19, 2026

Integrated Protocol for Assessing Meningeal Lymphatics: Cisterna Magna Injection, Lymph Node Imaging, Meningeal Dissection, and Whole-Mount Staining
Published on: May 29, 2026
[Stroke-like presentation of cerebral lymphoma]
Introduction:
The clinical presentation of primary cerebral lymphoma can take on many forms.
Case Report:
We report the case of a patient who experienced recurrent neurological events mimicking stroke with normal brain MRI. A late performed MRI showed a mesencephalic lesion. A biopsy was obtained and led to the diagnosis of primary B cell lymphoma.
Conclusion:
This observation illustrates the diagnostic challenge of this rare disorder with a poor prognosis.
Insights
Primary cerebral lymphoma presents diversely, often mimicking stroke. This case highlights a diagnostic challenge with a rare B cell lymphoma presenting as recurrent neurological events and a mesencephalic lesion.
Area of Science:
- Neurology
- Oncology
- Neuroimaging
Background:
- Primary cerebral lymphoma (PCL) is a rare central nervous system malignancy.
- PCL can manifest with varied clinical symptoms, complicating early diagnosis.
Observation:
- A patient presented with recurrent neurological deficits suggestive of stroke.
- Initial brain Magnetic Resonance Imaging (MRI) scans were unremarkable.
- A delayed MRI revealed a mesencephalic lesion, prompting further investigation.
Findings:
- Biopsy confirmed the diagnosis of primary B cell lymphoma.
- The patient's presentation mimicked cerebrovascular events due to the lymphoma's location and nature.
Implications:
- This case underscores the diagnostic difficulties associated with PCL.
- Prompt recognition and biopsy are crucial for managing this rare and aggressive condition.
Related Concept Videos
Hemorrhagic Stroke l: Introduction
Transient Ischemic Attack l: Introduction
Brain Abscess l: Introduction
Stroke: Introduction and Types
Hemorrhagic Stroke ll: Pathophysiology
Ischemic Stroke l: Introduction
