Related Experiment Video
Updated: Aug 19, 2026

Signal Acquisition, Score Interpretation, and Economics of a Non-Invasive Point-of-Care Test for Coronary Artery Disease
Published on: August 9, 2024
Estimation of disease-specific costs in health insurance claims: a comparison of three methods
1National Institute of Public Health, Department of Management Sciences, 2-3-6, Minami, Wako-shi, Saitama 351-0197, Japan. atoz@niph.go.jp
Objective:
To compare the accuracy and validity of three different methods (Proportional Disease Magnitude method [PDM] with two different magnitude estimations: arithmetic means with correction by the authors; Proportional Allotment Estimator [PAE] by Tango; Maximum Likelihood Estimator [MLE] also by Tango) for estimating disease-specific costs in health insurance claims.
Methods:
Application of the three methods to a computer-generated simulation dataset whose disease-specific costs were known and to actual outpatient claims whose disease-specific costs were unknown.
Outcome Measures:
For simulation data, the accuracy was assessed by correlation between known disease-specific costs and estimated disease-specific costs by the three methods. For actual claims, concurrent validity was assessed by inter-method correlations between pairs of the two methods.
Results:
All three methods showed good agreement and accuracy with the simulation data but marked disagreement when they applied to actual claims. MLE yielded an aggregate total of disease-specific costs exceeding the actual total by 21.3% and showed negative disease-specific costs in 18 out of 154 categories. Inter-method correlations showed that PDM with PAE and MLE correlated most strongly (R2 = 0.9022) while the least correlation was observed for PDM with arithmetic means and MLE (R2 = 0.6861).
Conclusion:
MLE is not usable for claims analysis but PDM yielded good estimates with two different methods of magnitude estimation using actual claims.
Related Concept Videos
Comparing the Survival Analysis of Two or More Groups
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Actuarial Approach
Consider the example of a high-risk surgical procedure with significant early-stage mortality. A two-year clinical study is conducted,...
Statistical Methods for Analyzing Epidemiological Data
Kaplan-Meier Approach
Drug Dosing in Renal Diseases: Estimation of Glomerular Filtration Rate Based on Serum Creatinine Concentration
