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Extreme hypervascularity and bruit in a treated hypothyroid goitre
S D Shenoy1, S Mathur, P G F Swift
1Children's Hospital, University Hospitals of Leicester NHS Trust, Leicester, UK.
Journal of Pediatric Endocrinology & Metabolism : JPEM
|February 1, 2005
Summary
A child
Area of Science:
- Pediatric Endocrinology
- Vascular Biology
- Thyroidology
Background:
- Hypothyroidism in early puberty requires thyroid hormone replacement therapy.
- Thyroid gland vascularity can be influenced by various physiological and pathological factors.
Observation:
- A child with hypothyroidism developed a neck bruit after thyroxine treatment.
- The bruit correlated with dilated superior thyroid arteries and increased goiter blood flow.
Findings:
- Histopathology revealed thyroid dyshormonogenesis and significantly increased vascularity.
- Widespread vascular endothelial growth factor (VEGF) staining was observed in the thyroid tissue.
- VEGF and other angiogenic factors likely contributed to goiter enlargement and hypervascularity.
Implications:
- This case highlights a potential link between VEGF-mediated angiogenesis and thyroid vascular changes post-treatment.
- Understanding these mechanisms is crucial for managing thyroid disorders in children.
- Further research into angiogenic factors in pediatric thyroid disease is warranted.
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