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Updated: Aug 19, 2026

Generation and Culturing of Primary Human Keratinocytes from Adult Skin
Published on: December 22, 2017
Keratinocyte growth factor: effects on keratinocytes and mechanisms of action
Ulrich auf demKeller1, Monika Krampert, Angelika Kümin
1Institute of Cell Biology, Department of Biology, ETH Zürich, Zürich, Switzerland.
Abstract:
Keratinocyte growth factor (KGF) is a potent and specific mitogen for different types of epithelial cells, and it can protect these cells from various insults. Due to these properties, it is of particular importance for the repair of injured epithelial tissues, and it is currently therapeutically explored for the treatment of radiation- and chemotherapy-induced mucosal epithelial damage in cancer patients. In this review we summarize the current knowledge on the role of KGF in tissue repair and cytoprotection, and we report on its mechanisms of action in keratinocytes.
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