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Updated: Jul 31, 2026

10:52
Chronic Constriction Injury of the Rat's Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain
Published on: September 21, 2015
Facial pain from visceral origin
Summary
Lung cancer can cause rare referred facial pain, often in the trigeminal nerve area. Early diagnosis and treatment of the lung tumor can significantly improve this persistent pain.
Area of Science:
- Neurology
- Oncology
Background:
- Unilateral facial pain, particularly in the trigeminal distribution, can be an unusual symptom of superior pulmonary lobe cancers.
- Referred facial pain is a rare clinical presentation, often linked to advanced lung malignancies.
Observation:
- A 65-year-old male smoker presented with persistent otalgia and left-sided mandibular pain unresponsive to analgesics.
- Initial investigations for common causes of facial pain were inconclusive.
- Dyspnea preceded the diagnosis of left lung cancer.
Findings:
- The patient's facial pain improved following radiotherapy and chemotherapy for lung cancer.
- Referred facial pain, potentially due to tenth cranial nerve invasion by upper lobe tumors, can manifest as otalgia and V3 distribution pain.
- Diagnosis of the underlying lung cancer can be delayed by months to years after pain onset.
Implications:
- This case highlights the importance of considering referred pain from lung cancer in patients with unexplained trigeminal facial pain.
- Prompt diagnosis and treatment of the primary lung tumor are crucial for managing cancer-related facial pain.
- Awareness of this rare presentation can aid clinicians in earlier diagnosis and intervention.
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