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[Varicella vaccine].

P Reinert1, I Hau-Rainsard

  • 1Service de pédiatrie, centre hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94010 Créteil, France. philippe.reinert@chicreteil.fr

Medecine Et Maladies Infectieuses
|February 1, 2005
PubMed
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This study details a live attenuated varicella vaccine derived from the OKA strain. The vaccine demonstrates high seroconversion rates and effective prevention of chickenpox in children.

Area of Science:

  • Virology
  • Immunology
  • Vaccinology

Context:

  • Varicella-zoster virus (VZV) infection, commonly known as chickenpox, poses a significant public health concern, particularly in pediatric populations.
  • Development of safe and effective vaccines is crucial for preventing VZV-related morbidity and mortality.

Purpose:

  • To describe the development and characterization of a live attenuated varicella vaccine derived from the OKA strain.
  • To evaluate the immunogenicity and efficacy of this vaccine in healthy children.

Summary:

  • A live attenuated varicella vaccine was produced by propagating the OKA strain virus through 11 passages at 34°C on HELF cells and subsequently in MRC-5 human diploid cell culture.
  • The resulting lyophilized vaccine contains a thermo-sensitive attenuated virus (inactivated at 39°C).

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  • In healthy children aged 12 months to 12 years, a single dose achieved seroconversion rates of 93%-100% and demonstrated at least 85% efficiency in preventing varicella over 2-4 years, with over 95% efficacy against severe forms.

    • Impact:

    • This live attenuated varicella vaccine offers a promising strategy for the prevention and control of chickenpox in children.
    • The vaccine's high efficacy and favorable safety profile contribute to reducing the burden of VZV infection.