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Updated: Aug 19, 2026

Biosynthesis of a Flavonol from a Flavanone by Establishing a One-pot Bienzymatic Cascade
Published on: August 14, 2019
Prenylflavonoids and phloroglucinol derivatives from hops (Humulus lupulus)
Feng Zhao1, Yuki Watanabe, Hajime Nozawa
1Central Laboratories for Key Technology, Kirin Brewery Co., Ltd., Yokohama-shi, Kanagawa 236-0004, Japan.
Abstract:
The ethyl acetate soluble fraction of hops (Humulus lupulus) showed potent inhibitory activity on the production of nitric oxide (NO) induced by a combination of LPS and IFN-gamma. Four known prenylflavonoids (1-4) and a new prenylflavonoid (5), hulupinic acid (6), lupulone (7), and its six new derivatives (8-13) were isolated from the active fraction. The structures were determined on the basis of physiochemical properties and spectroscopic analysis. Their inhibitory activities on the production of NO in macrophage RAW 264.7 cells were examined.
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