Related Experiment Video
Updated: Aug 19, 2026

Applications of Liquid-Chromatography Tandem Mass Spectrometry in Natural Products Research: Tropane Alkaloids as a Case Study
Published on: March 8, 2024
Three new taxane diterpenoids from Taxus sumatrana
Ya-Ching Shen1, Kuen-Ching Cheng, Yun-Chi Lin
1Institute of Marine Resources, National Sun Yat-sen University, 70 Lien-Hai Road, Kaohsiung, Taiwan 80424, Republic of China. ycshen@mail.nsysu.edu.tw
Abstract:
Phytochemical investigation of taxane diterpenoidal content of an acetone extract of the leaves and twigs of Taxus sumatrana has resulted in the isolation of three new taxoid compounds, tasumatrols E (1), F (2), and G (3) together with 13 known taxanes (5-16). The structures of these taxanes as well as their derivatives were established on the basis of spectroscopic analyses, especially 1D and 2D NMR. Compounds 1, 2, 12, and 16 exhibited significant cytotoxicity against human A-498, NCI-H226, A549, and PC-3 tumor cells.
Related Concept Videos
Drugs that Stabilize Microtubules
Drugs that Destabilize Microtubules
[3,3] Sigmatropic Rearrangement of 1,5-Dienes: Cope Rearrangement

