Related Experiment Video
Updated: Jun 17, 2026
10:40
Visualization and Analysis of Blood Flow and Oxygen Consumption in Hepatic Microcirculation: Application to an Acute Hepatitis Model
Published on: August 4, 2012
A note on Gutierrez's kinetics model for oxygen delivery to tissue
1Centre for Atmospheric Sciences, Indian Institute of Technology, Hauz Khas, New Delhi.
Bio Systems
|January 1, 1992
Summary
This study identifies a dimensional error in the Gutierrez model for oxygen delivery. Correcting the oxygen dissociation curve function provides accurate tissue oxygenation results under various conditions.
Area of Science:
- Physiology
- Biophysics
Background:
- The Gutierrez model (1986) is a significant model for understanding oxygen delivery to tissues.
- A key component of this model, the oxygen dissociation curve (ODC) function, has been identified as dimensionally incorrect.
Purpose of the Study:
- To address the dimensional inaccuracy in the Gutierrez model's oxygen dissociation curve function.
- To re-evaluate oxygen delivery to tissues using a dimensionally correct ODC function.
Main Methods:
- Analysis of the Gutierrez model (1986).
- Implementation of a dimensionally correct function for the oxygen dissociation curve (ODC).
- Re-calculation of oxygen delivery parameters.
Main Results:
- Identified a critical dimensional error in the ODC function used in the Gutierrez model.
- The revised analysis yields accurate oxygen delivery calculations.
- Corrected results are provided for normoxic, hypoxic, and anemic conditions.
Conclusions:
- The dimensional correctness of the oxygen dissociation curve function is crucial for accurate modeling of oxygen delivery.
- The corrected model provides reliable predictions of tissue oxygenation across different physiological states.
Related Concept Videos
01:20Respiration and Gaseous Exchange
The intricate interplay between the cardiovascular and respiratory systems is crucial for efficiently transporting respiratory gases throughout the body. Let us explore the cardiovascular system's multifaceted functions, emphasizing its pivotal role in gas exchange.
Respiration involves the exchange of gases, especially oxygen (O2) and carbon dioxide (CO2), between the alveoli and body cells, a process facilitated by blood circulation. As a result, the cardiovascular system, which involves the...
Respiration involves the exchange of gases, especially oxygen (O2) and carbon dioxide (CO2), between the alveoli and body cells, a process facilitated by blood circulation. As a result, the cardiovascular system, which involves the...
01:27Oxygen Transport in the Blood
Hemoglobin (Hb) is a crucial molecule in the human body, consisting of four polypeptide chains, each bound to an iron-containing heme group. This unique structure enables hemoglobin to bind to oxygen, with each molecule capable of combining with four molecules of oxygen, leading to rapid and reversible oxygen loading. When fully loaded with oxygen, it is called oxyhemoglobin, while hemoglobin that has released oxygen is called reduced hemoglobin or deoxyhemoglobin. As hemoglobin binds oxygen,...
01:15Model Approaches for Pharmacokinetic Data: Physiological Models
Physiological models in pharmacokinetics are instrumental in understanding the distribution and elimination of drugs within the body. These models describe the drug concentration within target organs, influenced by factors such as drug uptake, tissue volume, and blood flow. Drug uptake is governed by the partition coefficient, which signifies the drug concentration ratio in tissue to that in the blood. The blood flow rate to a specific tissue is expressed as Qt, and the rate of change in tissue...
00:57Physiological Pharmacokinetic Models: Blood Flow-Limited Versus Diffusion-Limited Models
Physiological pharmacokinetic models, often called flow-limited or perfusion models, typically assume a swift drug distribution between tissue and venous blood, creating a rapid drug equilibrium. This premise is based on the idea that drug diffusion is extremely fast, and the cell membrane presents no barrier to drug permeation. In this scenario, where no drug binding occurs, the drug concentration in the tissue equals that of the venous blood leaving the tissue. This greatly simplifies the...
01:07Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance
Drug transporters are critical in drug absorption, distribution, and excretion processes. They should be included in physiological-based pharmacokinetic (PBPK) models, which help predict human drug disposition. However, predicting this is challenging during drug development, especially when liver transport is involved. However, with a realistic representation of body transport processes, an accurate model may be possible.
A recent model describes pravastatin's hepatobiliary excretion, mediated...
A recent model describes pravastatin's hepatobiliary excretion, mediated...
01:18Nonlinear Pharmacokinetics: Michaelis-Menten Equation
The Michaelis–Menten equation is a fundamental model for describing capacity-limited kinetics in drug metabolism. It offers insights into the rate of decline of plasma drug concentration Cp over time, with Vmax and KM as pivotal parameters.
Vmax represents the maximum achievable process rate, while KM, known as the Michaelis constant, signifies the drug concentration at which the process rate reaches half its maximum. This relationship between Vmax, KM, and Cp gives rise to three distinct...
Vmax represents the maximum achievable process rate, while KM, known as the Michaelis constant, signifies the drug concentration at which the process rate reaches half its maximum. This relationship between Vmax, KM, and Cp gives rise to three distinct...