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Related Experiment Videos

Outcomes for children with acute myocarditis.

Robert F English1, Janine E Janosky, Jose A Ettedgui

  • 1Pediatric Cardiovascular Center, Division of Pediatric Cardiology, Department of Pediatrics, University of Florida, Jacksonville, FL 32207, USA. robert.english@jax.ufl.edu

Cardiology in the Young
|February 1, 2005
PubMed
Summary

The best treatment for pediatric myocarditis remains unclear. This study found no significant difference in outcomes between steroid therapy, intravenous immune globulin, or no treatment for children with myocarditis.

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Area of Science:

  • Pediatric Cardiology
  • Infectious Diseases
  • Immunology

Background:

  • Myocarditis in children has an unknown optimal treatment.
  • Outcomes vary significantly, impacting long-term cardiac health.
  • Viral infections are a common cause of pediatric myocarditis.

Purpose of the Study:

  • To evaluate treatment outcomes in a large series of children diagnosed with myocarditis.
  • To compare the efficacy of different therapeutic approaches, including steroids and intravenous immune globulin.
  • To identify factors influencing recovery, death, or transplantation in pediatric myocarditis.

Main Methods:

  • Retrospective review of pediatric myocarditis cases at Children's Hospital of Pittsburgh since 1985.
  • Inclusion criteria: biopsy-proven myocarditis or cardiac dysfunction with viral infection proof.

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  • Outcome assessment: complete recovery, incomplete recovery, death, or transplantation.

    • Main Results:

    • Of 41 patients, 66% achieved complete recovery, 10% had incomplete recovery, and 24% died or underwent transplantation.
    • Steroid and intravenous immune globulin (IVIG) therapies showed no significant advantage over no treatment.
    • Survival free from death or transplantation was 81% at 1 year and 74% at 5 years, irrespective of treatment modality.

    Conclusions:

    • Current treatment strategies, including steroids and IVIG, do not appear to significantly alter outcomes in pediatric myocarditis.
    • Data suggest a need for randomized controlled trials to establish effective treatments.
    • Further research is essential to develop and validate new therapeutic interventions for pediatric myocarditis.