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Updated: Aug 19, 2026

Translational Rabbit Model of Chronic Cardiac Pacing
Published on: January 6, 2023
Thirty years of experience with epicardial pacing in children
Nicolas Noiseux1, Paul Khairy, Anne Fournier
1Department of Cardiovascular Surgery, Children's Hospital Boston, Harvard Medical School, USA.
Insights
Epicardial pacing is a reliable method for children, though reintervention is common within five years. Long-term safety is good, but careful follow-up is essential for pediatric patients requiring pacemakers.
Area of Science:
- Pediatric Cardiology
- Biomedical Engineering
- Cardiac Electrophysiology
Background:
- Epicardial pacing is often preferred for pediatric patients due to anatomical considerations.
- Long-term safety data for epicardial pacemakers in children is crucial for clinical decision-making.
Purpose of the Study:
- To assess the long-term safety and efficacy of epicardial pacemakers in a pediatric population.
- To identify risk factors associated with reintervention in children with epicardial pacing.
Main Methods:
- Retrospective review of 181 epicardial pacemakers and 260 electrodes implanted in 122 children between 1971 and 2001.
- Analysis of patient data over a total follow-up of 789 patient-years.
- Statistical analysis including univariate and multivariate risk factor identification for reintervention.
Main Results:
- Reintervention was required in 75 patients (61.5%) after a median of 5.0 years, primarily due to battery depletion (60%) and electrode issues (36%).
- Median sternotomy approach (RR 2.1, p=0.0256) and pacing indications other than atrioventricular block (RR 1.7, p=0.0314) were significant predictors of reintervention.
- One death was attributed to pacemaker dysfunction; overall mortality was low.
- Longevity of replacement pacemakers was comparable to initial implants.
Conclusions:
- Epicardial pacing demonstrates reliability and acceptable long-term safety in children, with low morbidity and mortality.
- A significant need for reintervention exists within five years, highlighting the importance of vigilant follow-up protocols.
- Further research into optimizing lead and battery longevity may reduce reintervention rates.
Abstract:
Due to underlying cardiovascular anatomy and size, epicardial pacing may be the preferred method of pacing in small children. To assess long-term safety, we reviewed all epicardial pacemakers implanted in children between 1971 and 2001. We found that 122 patients, with a median age of 5.4 years, had a total of 181 pacemakers and 260 electrodes implanted over a total follow-up of 789 patient-years. Of the total, 12 patients died after the first implantation, with one death attributable to dysfunction of the pacemaker. Reintervention was required in 75 patients after 5.0 +/- 3.2 years, due to depletion of the battery in 45 patients (60%), fracture or dysfunction of electrodes in 27 patients (36%), and infection in 3 patients (4%). In univariate analyses, risk factors for reintervention were an approach via a median sternotomy, with a relative risk of 2.3 (p = 0.0087), and an indication for pacing other than atrioventricular block, with a relative risk of 1.7 (p = 0.0314). In multivariate analyses, the approach via the median sternotomy independently predicted the need for reintervention, with a relative risk of 2.1, and 95% confidence intervals from 1.1 to 4.1 (p = 0.0256). The longevity of the second pacemaker and/or its electrode, assessed in 26 patients, was 3.7 +/- 2.6 years, not shorter than the first implantation (p = 0.4037). We conclude that epicardial pacing is a reliable means of achieving permanent pacing in children, with low morbidity and mortality. A substantial proportion, nonetheless, requires reintervention within five years, warranting meticulous follow-up.
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