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Echocardiographic Evaluation of Atrial Communications before Transcatheter Closure
Published on: February 8, 2022
Cleft mitral valve in transposition with intact ventricular septum
Samuel Menahem1, Robert H Anderson
1Department of Cardiology, Royal Children's Hospital & Monash Medical Centre, Melbourne, Australia. sam.menahem@rch.org.au
Cardiology in the Young
|February 1, 2005
Summary
This study details two cases of isolated mitral valve cleft in transposition with intact ventricular septum. These findings support the theory that this condition represents the spectrum
Area of Science:
- Cardiology
- Developmental Biology
- Congenital Heart Disease
Background:
- Transposition with intact ventricular septum is a complex congenital heart defect.
- The Taussig-Bing malformation is a related spectrum of cardiac anomalies.
- Understanding the developmental origins of these conditions is crucial for diagnosis and treatment.
Observation:
- Two cases of isolated mitral valve cleft were identified in transposition with intact ventricular septum.
- The mitral valve cleft was consistently located leftward in the pulmonary leaflet.
- This leftward positioning mirrors clefts observed in the Taussig-Bing malformation.
Findings:
- The observed mitral valve clefts provide further evidence for a shared developmental pathway.
- The findings suggest that transposition with intact ventricular septum may be an endpoint of the Taussig-Bing spectrum.
- This anatomical observation refines our understanding of cardiac development in complex congenital heart disease.
Implications:
- These findings enhance the understanding of the spectrum of cardiac development.
- This knowledge can aid in the diagnosis and classification of congenital heart defects.
- Further research into the developmental mechanisms is warranted.
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