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Related Experiment Videos

Amorphous oxide--a platform for drug delivery.

Chun-Ming Shih1, Shing-Jong Lin, Yea-Yang Su

  • 1Graduate Institute of Medical Sciences, School of Medicine, Taipei Medical University, Taipei 110, Taiwan.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|February 1, 2005
PubMed
Summary

This study explores using an oxide layer as a polymer-free drug-loading platform for medical devices, like cardiovascular stents. Results show amorphous oxide effectively replaces polymer coatings, reducing risks such as inflammation and thrombosis.

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Area of Science:

  • Biomaterials Science
  • Cardiovascular Engineering
  • Surface Chemistry

Background:

  • Polymer coatings on metallic medical devices can cause adverse effects like thrombosis and inflammation post-implantation.
  • Current drug-eluting stent technology relies on polymer coatings for drug delivery.

Purpose of the Study:

  • To investigate the potential of an amorphous oxide layer as a polymer-free platform for drug loading on cardiovascular stents.
  • To evaluate the efficacy of an oxide layer as a substitute for polymer coatings in drug delivery systems.

Main Methods:

  • Experimental studies involving cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), and electron spectroscopy for chemical analysis (ESCA).
  • High-performance liquid chromatography (HPLC) and activated clotting time (ACT) assays were used to confirm drug loading and elution.

Related Experiment Videos

  • Amorphous oxide film on 316LVM stainless steel wire was utilized for heparin loading and elution studies.

    • Main Results:

    • Successful loading and elution of heparin onto the amorphous oxide film were confirmed.
    • The amorphous oxide layer demonstrated potential for drug delivery applications.
    • Experimental data validated the feasibility of using oxide films for drug carriage.

    Conclusions:

    • Amorphous oxide layers can serve as an effective polymer-free alternative for drug loading on medical devices, particularly cardiovascular stents.
    • This approach shows promise in minimizing risks associated with polymer coatings, including metallic corrosion, inflammation, late-thrombosis, and restenosis.
    • The findings suggest a new direction for developing safer and more effective drug-eluting stents.