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Related Experiment Videos

Sustained interferon-gamma delivery from a photocrosslinked biodegradable elastomer.

Frank Gu1, Husam M Younes, Ayman O S El-Kadi

  • 1Department of Chemical Engineering, Queen's University, Kingston, ON, Canada K7L 3N6.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|February 1, 2005
PubMed
Summary

A new biodegradable elastomer delivery system using osmotic pressure successfully released bioactive interferon-gamma for 21 days. This protein drug delivery method shows promise for sustained, localized therapeutic applications.

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Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Biotechnology

Background:

  • Localized protein therapeutics require sustained release within a therapeutic window.
  • Existing delivery devices often fail to meet these requirements, limiting clinical applications.

Purpose of the Study:

  • To design and evaluate a novel biodegradable elastomer system for sustained, localized protein delivery.
  • To overcome limitations of current protein delivery devices using osmotic pressure and photocrosslinking.

Main Methods:

  • Synthesized a photocrosslinked biodegradable elastomer from end-terminal acrylated star-poly(epsilon-caprolactone-co-D,L-lactide).
  • Incorporated Interferon-gamma (IFN-gamma) into the elastomer matrix.
  • Utilized an osmotic pressure delivery mechanism for controlled release.

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  • Assessed protein bioactivity using cell-based assays and release kinetics.

    • Main Results:

    • The optimized formulation achieved a constant release rate of 23 ng/day of IFN-gamma over 21 days.
    • Over 83% of the released IFN-gamma was confirmed to be bioactive via cell-based assays.
    • Co-lyophilized bovine serum albumin demonstrated equivalent release kinetics to IFN-gamma, indicating formulation stability.

    Conclusions:

    • The developed osmotic pressure-driven, photocrosslinked biodegradable elastomer system effectively delivers bioactive protein therapeutics.
    • This formulation holds significant potential for clinical applications requiring sustained, localized protein drug delivery.