Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

CD4(+) CD25(+) regulatory T cell selection.

Andrew J Caton1, Cristina Cozzo, Joseph Larkin

  • 1The Wistar Institute, 3601 Spruce St., Philadelphia, PA 19104, USA. caton@wistar.upenn.edu

Annals of the New York Academy of Sciences
|February 1, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precision CRISPR annotation of the functional enhancer landscape in primary human T cells.

bioRxiv : the preprint server for biology·2026
Same author

Quantification and comparison of anti-AAV9 and anti-AAVrh74 antibodies in plasma and human milk: Implications for AAV-based gene therapy candidacy.

Journal of neuromuscular diseases·2025
Same author

A peptide mimic of SOCS1 modulates equine peripheral immune cells <i>in vitro</i> and ocular effector functions <i>in vivo</i>: implications for recurrent uveitis.

Frontiers in immunology·2025
Same author

Deletion of metal transporter Zip14 reduces major histocompatibility complex II expression in murine small intestinal epithelial cells.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Uveitis treatment in the Childhood Arthritis and Rheumatology Research Alliance (CARRA) Registry: response to tumour necrosis factor inhibitors.

Clinical and experimental rheumatology·2024
Same author

Rapidly Progressive Idiopathic Pyoderma Gangrenosum in a Pediatric Patient Successfully Treated With Infliximab.

Pediatric dermatology·2024
Same journal

Multiomics Profiling During Autoimmune Demyelination Highlights a Complex Regulatory Role for Ataxin-1 in B Cells.

Annals of the New York Academy of Sciences·2026
Same journal

Global Trends in Light Pollution and Their Relationship With Socioeconomic Factors.

Annals of the New York Academy of Sciences·2026
Same journal

Wired for Corruption: Inter-Brain Synchrony Encodes Bribery-Related Value Information and Predicts Bribery Agreement.

Annals of the New York Academy of Sciences·2026
Same journal

LM-YOLO: A Lightweight Multi-Scale Enhanced Model for Forest Smoke Detection Using Unmanned Aerial Vehicles.

Annals of the New York Academy of Sciences·2026
Same journal

Polyrhythm Perception and Production: A Scoping Review.

Annals of the New York Academy of Sciences·2026
Same journal

DARTS-CNN-BiLSTM: Intelligent Fault Diagnosis for Computer Numerical Control Machine Tool Feed System.

Annals of the New York Academy of Sciences·2026
See all related articles

Regulatory T cells prevent autoimmunity. Self-peptide interactions during immune development determine if autoreactive T cells become regulatory CD4(+) CD25(+) T cells or are deleted, influencing autoimmune disease risk.

Area of Science:

  • Immunology
  • T cell biology
  • Autoimmunity

Background:

  • Regulatory T cells are vital for preventing autoimmune diseases.
  • Understanding the development of regulatory T cells is crucial for immune tolerance.
  • Self-peptides play a significant role in shaping the T cell repertoire.

Purpose of the Study:

  • To investigate how self-peptides influence the development of regulatory CD4(+) T cells during immune repertoire formation.
  • To determine the role of T cell receptor (TCR) affinity in the selection of regulatory T cells.
  • To explore the peripheral expansion and behavior of regulatory T cells in response to self-antigens.

Main Methods:

  • Development of transgenic mouse models expressing influenza virus hemagglutinin (HA) and specific TCRs.

Related Experiment Videos

  • Analysis of thymocyte selection processes based on TCR affinity for self-peptides.
  • Investigation of CD4(+) CD25(+) regulatory T cell proliferation in response to self-peptides and lymphopenia.

    • Main Results:

    • Self-peptide interactions can induce autoreactive thymocytes to become CD4(+) CD25(+) regulatory T cells.
    • TCR affinity for self-peptides dictates thymic selection outcomes (deletion vs. regulatory T cell generation).
    • CD4(+) CD25(+) regulatory T cells proliferate in response to their selecting self-peptide in the periphery but not lymphopenia.

    Conclusions:

    • Specificity for self-peptides directs both thymic selection and peripheral expansion of CD4(+) CD25(+) regulatory T cells.
    • Differential responsiveness to cytokine vs. self-peptide signals may guide regulatory T cell accumulation.
    • These findings provide insights into mechanisms controlling immune tolerance and preventing autoimmunity.