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Comparative study of oral versus subcutaneous B:9-23 insulin peptide in Balb/c mice as an experimental model for
Devasenan Devendra1, Johanna Paronen, Edwin Liu
1Barbara Davis Center for Childhood Diabetes, University of Colorado Health Sciences Center, Denver, CO 80262, USA.
Annals of the New York Academy of Sciences
|February 1, 2005
Abstract:
Insulin peptide B:9-23 (amino acids 9 to 23 of the B chain) can induce immune targeting of insulin and islets in normal Balb/c mice. The insulin autoantibodies induced react with insulin and not the immunizing peptide. Oral administration of insulin as well as subcutaneous insulin can sensitize to insulin.
