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CCL25 enhances CD103-mediated lymphocyte adhesion to E-cadherin
Anna Ericsson1, Anu Arya, William Agace
1Immunology Section, Department of Cell and Molecular Biology, Lund University, BMC I-13, SE-22184 Lund, Sweden. Anna.Ericsson@immuno.lu.se
Annals of the New York Academy of Sciences
|February 1, 2005
Abstract:
Our results demonstrate that (1) CD103 is upregulated on CD8(+) T cells subsequent to their entry into the small intestinal epithelium, and (2) that the chemokine CCL25 enhances CD103-mediated adhesion to E-cadherin. These results suggest a novel role for chemokines in modulating interactions between lymphocytes and epithelial cells at mucosal surfaces.