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Transforming growth factor-{beta} regulates susceptibility of epithelial apoptosis in murine model of colitis

Hirotake Sakuraba1, Yoh Ishiguro, Kazufumi Yamagata

  • 1First Department of Internal Medicine, Hirosaki University School of Medicine, 5 Zaifu-cho, Hirosaki, Aomori 036-8562, Japan. hirotake@infoaomori.ne.jp

Annals of the New York Academy of Sciences
|February 1, 2005
PubMed

Transforming growth factor (TGF)-beta has a key role in intestinal homeostasis. Our present data suggest that TGF-beta, which was constitutively expressed by lamina propria mononuclear cells and epithelium, affected epithelial cells. Abnormal suppression of TGF-beta could enhance the sensitivity of epithelial cells to apoptosis associated with interferon-gamma in DSS-induced colitis.

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