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Is oral tolerance correlated with IgE levels and mast cell numbers?
Antonio Carlos da Silva1, Maria F S Silva, Cristina Bianchi
1Laboratório de Imunobiologia, Departamento Biologia Celular e Genética, Instituto de Biologia, UERJ, Rua S. Francisco Xavier, 524, PHLC, Maracanã, Rio de Janeiro, RJ, Brasil, CEP 20.559-900. dasilva@uerj.br
Annals of the New York Academy of Sciences
|February 1, 2005
Abstract:
A triple genetic association between serum IgE levels, mast cell numbers, and susceptibility to oral tolerance was observed in mice genetically selected to extreme phenotypes of oral tolerance (susceptibility and resistance), suggesting a coadaptation of genes controlling these traits.
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The oral microbiome includes a complex ecosystem comprising over 700 microbial species, identified through genomic sequencing and culture-based analyses to date. This community includes a core microbiome, found universally among individuals, and a variable component influenced by environmental factors such as diet, lifestyle, and host genetics. Site-specific conditions, including oxygen gradients, pH levels, and nutrient availability, determine the spatial distribution of these microorganisms...

