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Circulating beta amyloid protein is elevated in patients with acute ischemic stroke
1Department of Neurology, Ajou University School of Medicine, Suwon, South Korea.
Journal of Neural Transmission (Vienna, Austria : 1996)
|February 1, 2005
Summary
Elevated beta amyloid (Abeta1-40) levels were found in patients with acute ischemic stroke compared to controls. This suggests a link between stroke and Alzheimer's disease pathogenesis, with higher Abeta1-40 in larger strokes.
Area of Science:
- Neurology
- Neuroscience
- Pathophysiology
Background:
- Emerging evidence links ischemic strokes to Alzheimer's disease (AD) pathogenesis.
- Beta-amyloid (Abeta), a key component of AD plaques, may originate from ischemic brain tissue or activated platelets.
Purpose of the Study:
- To investigate serum Abeta levels in patients with acute ischemic stroke.
- To explore the relationship between Abeta levels and stroke characteristics.
Main Methods:
- Prospective enrollment of 62 acute ischemic stroke patients and 27 controls.
- Serum Abeta1-40 and P-selectin levels measured via Sandwich-ELISA.
- Subgroup analysis based on stroke type, pathogenesis, and infarct size.
Main Results:
- Ischemic stroke patients exhibited significantly higher serum Abeta1-40 levels than controls (140.2 vs 88.44 pg/ml).
- Higher Abeta1-40 levels were observed in cardioembolic and large artery atherosclerotic strokes compared to small vessel disease.
- Infarct size and initial NIHSS score positively correlated with serum Abeta1-40.
Conclusions:
- Elevated circulating Abeta1-40 in ischemic stroke patients suggests it may be a consequence of ischemic brain injury.
- These findings support a potential role for ischemic events in Alzheimer's disease development.