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[Effects of low dose colforsin daropate hydrochloride in patients undergoing off-pump coronary artery bypass

Keiichi Sha1, Toshikazu Okita, Aki Fujiwara

  • 1Department of Anesthesiology, Nara Medical University, Kashihara 634-0063.

Masui. the Japanese Journal of Anesthesiology
|February 3, 2005
PubMed

Insights

Low dose colforsin daropate hydrochloride (CDH) effectively manages hemodynamics during off-pump coronary artery bypass grafting (CABG). CDH prevents pulmonary pressure increases while improving cardiac output and reducing vascular resistance.

Area of Science:

  • Cardiovascular Surgery
  • Anesthesiology
  • Pharmacology

Background:

  • Retrospective evaluation of low-dose colforsin daropate hydrochloride (CDH) in 12 patients.
  • Focus on patients undergoing off-pump coronary artery bypass grafting (CABG).

Purpose of the Study:

  • To assess the effectiveness of low-dose CDH in maintaining hemodynamic stability during off-pump CABG.
  • To evaluate the impact of CDH on key hemodynamic parameters throughout the procedure.

Main Methods:

  • Intravenous administration of low-dose CDH (0.05-0.1 microg x kg(-1) x min(-1)) from sternotomy to anastomosis completion.
  • Comprehensive hemodynamic monitoring including heart rate, blood pressure, cardiac output, and vascular resistance before, during, and after anastomosis.

Main Results:

  • CDH infusion prevented significant increases in mean pulmonary artery pressure, right atrial pressure, and pulmonary artery wedge pressure.
  • Systolic blood pressure remained stable, while heart rate, cardiac output, systemic vascular resistance (SVR), and pulmonary vascular resistance (PVR) showed significant changes.
  • Specifically, cardiac output increased, and SVR and PVR decreased post-infusion.

Conclusions:

  • Low-dose CDH is effective in preventing adverse hemodynamic changes during off-pump CABG.
  • The drug enhances cardiac output and reduces vascular resistance without compromising systolic blood pressure.
  • Recommended for use from sternotomy to the end of coronary artery anastomosis in off-pump CABG patients.
Abstract

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