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Predictive value of high-sensitivity C-reactive protein in patients with idiopathic dilated cardiomyopathy

Steffen Lamparter1, Wolfram Grimm

  • 1Department of Cardiology, Hospital of the Philipps-University of Marburg, Germany.

Pacing and Clinical Electrophysiology : PACE
|February 3, 2005
PubMed

Insights

High-sensitivity C-reactive protein (hsCRP) predicts transplant-free survival in idiopathic dilated cardiomyopathy (IDC). However, hsCRP did not predict major arrhythmic events in IDC patients.

Area of Science:

  • Cardiology
  • Biomarkers
  • Inflammation

Background:

  • Idiopathic dilated cardiomyopathy (IDC) is a significant cause of heart failure.
  • Prognostic markers are crucial for managing IDC patients.
  • High-sensitivity C-reactive protein (hsCRP) is an inflammatory marker with potential prognostic value.

Purpose of the Study:

  • To investigate the prognostic value of serum hsCRP levels in patients with IDC.
  • To assess the association of hsCRP with major arrhythmic events and transplant-free survival.

Main Methods:

  • Serum hsCRP levels were measured at cardiac catheterization in 198 IDC patients.
  • Patients were stratified by median hsCRP (2 mg/dL).
  • Follow-up averaged 69 months, assessing arrhythmic events and transplant-free survival using multivariate analysis.

Main Results:

  • No significant difference in major arrhythmic events between low and high hsCRP groups.
  • Left ventricular ejection fraction (LVEF) was the sole significant predictor of arrhythmic risk.
  • Higher hsCRP levels were associated with increased rates of death or cardiac transplantation (36% vs. 22%, P < 0.05).
  • Both hsCRP and LVEF independently predicted transplant-free survival.

Conclusions:

  • Serum hsCRP has independent prognostic value for transplant-free survival in IDC patients.
  • hsCRP does not aid in stratifying arrhythmic risk in this population.
  • LVEF remains a key predictor for both arrhythmic risk and overall survival in IDC.

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