Related Experiment Video

Updated: Aug 19, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Marked improvement in left ventricular function and significant reverse left ventricular remodeling within 3 months

Reinhard C Funck1, Susanne Koelsch, Stefan Waldhans

  • 1Clinic for Cardiology, Philipps University Marburg, Marburg, Germany. funck@mailer.uni-marburg.de

Pacing and Clinical Electrophysiology : PACE
|February 3, 2005
PubMed

Insights

Cardiac resynchronization therapy (CRT) significantly improves heart function in dilated cardiomyopathy patients. CRT reduces left ventricular volumes and increases ejection fraction within six months, promoting reverse remodeling.

Area of Science:

  • Cardiology
  • Medical Devices
  • Heart Failure Management

Background:

  • Dilated cardiomyopathy (DCM) often involves impaired left ventricular (LV) function and remodeling.
  • Cardiac resynchronization therapy (CRT) is a treatment option for heart failure patients with specific electrical conduction abnormalities.

Purpose of the Study:

  • To evaluate the effects of CRT on reverse LV remodeling and LV function in DCM patients.
  • To assess changes in LV dimensions, volumes, and ejection fraction during the initial 6 months of CRT.

Main Methods:

  • Prospective monitoring of 34 DCM patients with left bundle branch block receiving CRT.
  • Echocardiography (M-mode and 2D) performed at baseline, 3 months, and 6 months post-implantation.
  • Measurement of LV end-diastolic diameter (LVEDD), LV end-systolic diameter (LVESD), LV end-diastolic volume (LVEDV), LV end-systolic volume (LVESV), and LV ejection fraction (LVEF).

Main Results:

  • Significant reduction in QRS duration from 169.7 ms to 144.1 ms post-CRT.
  • Significant decreases in LVEDD, LVESD, and LVESV observed at 3 and 6 months.
  • Significant increase in LVEF from 23% at baseline to 39% at 6 months.
  • CRT induced prominent reverse LV remodeling and improved LV function.

Conclusions:

  • CRT effectively induces reverse LV remodeling in DCM patients.
  • CRT significantly improves LV function, evidenced by increased LVEF within months.
  • CRT is a valuable therapeutic strategy for improving cardiac function in selected DCM patients.

More Related Videos

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents07:26

Studying Left Ventricular Reverse Remodeling by Aortic Debanding in Rodents

Published on: July 14, 2021

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System10:17

Real-Time Cardiac Mapping with a Noninvasive Imageless Electrocardiographic Imaging System

Published on: April 11, 2025

Related Concept Videos

Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy IV: Restrictive Cardiomyopathy01:29

Cardiomyopathy IV: Restrictive Cardiomyopathy

Restrictive cardiomyopathy (RCM) is a rare heart muscle disease characterized by impaired ventricular filling due to stiffened ventricular walls, leading to significant diastolic dysfunction.EtiologyRestrictive cardiomyopathy can arise from both inherited and acquired diseases, many of which are systemic. It is categorized into four main types: infiltrative, storage, non-infiltrative, and endomyocardial diseases.Infiltrative diseases, such as amyloidosis, lead to RCM by depositing amyloid...