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Related Experiment Videos

Acute haemostatic changes in accidentally traumatised dogs.

R Mischke1

  • 1Small Animal Clinic, Hannover School of Veterinary Medicine, Bischofsholer Damm 15, 30173 Hannover, Germany. reinhard.mischke@tihi-hannover.de

Veterinary Journal (London, England : 1997)
|February 3, 2005
PubMed
Summary

Acutely traumatized dogs frequently exhibit decompensated consumption of hemostatic components. This study reveals significant decreases in platelet count and coagulation factors, indicating severe hemostatic system alterations in injured dogs.

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Area of Science:

  • Veterinary Medicine
  • Hematology
  • Trauma Pathophysiology

Background:

  • Traumatic injuries in dogs can significantly impact physiological systems.
  • The hemostatic system plays a critical role in managing bleeding and maintaining vascular integrity.
  • Understanding hemostatic alterations post-trauma is crucial for effective clinical management.

Purpose of the Study:

  • To investigate alterations in the hemostatic system of dogs within 24 hours of natural injury.
  • To assess the levels of coagulation factors, inhibitors, and fibrinolytic components.
  • To correlate hemostatic changes with the severity of trauma.

Main Methods:

  • Studied 30 acutely traumatized dogs with various injuries, including bone fractures and thoracic/abdominal trauma.

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  • Assessed platelet count, coagulation factor activities, and levels of inhibitors (antithrombin, protein C) and plasminogen.
  • Measured alpha2-plasmin inhibitor activity, fibrinogen concentration, and fibrin(ogen) degradation products.

    • Main Results:

    • Significant decreases observed in platelet count and most coagulation factors (P < 0.01).
    • Elevated concentrations of soluble fibrin and/or fibrin(ogen) degradation products were noted in most animals (P < 0.0001).
    • Fibrinogen and alpha2-plasmin inhibitor levels remained unchanged, suggesting their role as acute phase reactants.

    Conclusions:

    • Acutely traumatized dogs frequently present with decompensated consumption of hemostatic components.
    • The study highlights widespread deficiencies in the coagulation system following trauma.
    • Findings underscore the critical role of hemostatic monitoring in veterinary trauma care.