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Updated: Jan 5, 2026
Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
Published on: August 31, 2019
[Preparation of stearic acid solid lipid nanoparticles containing podophyllotoxin]
Fang-ming Xie1, Kang Zeng, Guo-feng Li
1Department of Dermatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.
Objective:
To improve the therapeutic efficacy and reduce the adverse effect of podophyllotoxin (PPT) by wrapping it in stearic acid solid lipid nanoparticles.
Methods:
Stearic acid solid lipid nanoparticles containing podophyllotoxin was prepared using modified microemulsion technique, whose morphology was examined by transmission electron microscope. High-performance of liquid chromatography was employed to determine the entrapment efficiency of PPT in the nanoparticles.
Result:
The entrapment efficiency of PPT in the nanoparticles was 85.6% and the mean diameter of the particles was 56.5+/-25.8 nm.
Conclusion:
The stearic acid solid lipid nanoparticles has high entrapment efficiency for PPT and is homogeneous in size, which can be a promising targeted preparation for epidermal delivery.
