Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biomarkers: mining the biofluid proteome.

Timothy D Veenstra1, Thomas P Conrads, Brian L Hood

  • 1Laboratory of Proteomics and Analytical Technologies, SAIC-Frederick, Inc., National Cancer Institute at Frederick, Frederick, MD 21702-1201, USA. veenstra@ncifcrf.gov

Molecular & Cellular Proteomics : MCP
|February 3, 2005
PubMed
Summary

Proteomics offers hope for identifying novel cancer biomarkers using mass spectrometry (MS). Despite challenges in sample handling and analysis, rapid advances in biofluid characterization promise future diagnostic and treatment monitoring platforms.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Surgical Approaches to Pineal Region Tumors.

Advances and technical standards in neurosurgery·2026
Same author

Decompression with or without Duraplasty for Chiari I and Syringomyelia.

The New England journal of medicine·2026
Same author

Surgical revascularization versus nonsurgical management in children with symptomatic moyamoya arteriopathy: a North American multicenter cohort study.

Journal of neurosurgery. Pediatrics·2026
Same author

Postoperative Visual Outcomes in Pediatric Craniopharyngioma: A Comparison of Endoscopic Endonasal and Transcranial Approaches.

Journal of pediatric hematology/oncology·2026
Same author

Hemispherectomy in infants: an institutional experience with 21 patients.

Journal of neurosurgery. Pediatrics·2026
Same author

The Soul of Pediatric Neurosurgery: Wellness as a Path to Purpose.

Pediatric neurosurgery·2026

Area of Science:

  • Biochemistry
  • Biotechnology
  • Medical Diagnostics

Background:

  • Proteomics utilizes advanced technologies like mass spectrometry (MS) to analyze proteins in complex biological samples.
  • Identifying novel biomarkers for diseases, including cancer, is a key goal of proteomic research.
  • Biofluids such as plasma and serum are primary targets for biomarker discovery due to their accessibility.

Purpose of the Study:

  • To highlight the potential of proteomics in identifying novel disease biomarkers.
  • To discuss the challenges and advancements in proteomic analysis of biofluids.
  • To project the future development of diagnostic and therapeutic monitoring platforms.

Main Methods:

  • Mass spectrometry (MS) is employed for high-throughput protein identification in biofluids.

Related Experiment Videos

  • Proteomic techniques are used for the comprehensive characterization of complex biological samples.
  • Discovery-driven approaches are central to current proteomic research.

    • Main Results:

    • Proteomic technologies can identify hundreds of proteins in biofluids like plasma and serum.
    • Significant challenges exist in standardization of sample collection and analytical processes.
    • Rapid advancements are being made in the characterization of biofluids using proteomic methods.

    Conclusions:

    • Proteomics holds significant promise for the discovery of novel biomarkers for diseases such as cancer.
    • Overcoming standardization issues is crucial for reliable proteomic biomarker discovery.
    • Future developments in proteomics are expected to yield highly specific platforms for disease diagnosis and treatment monitoring.