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Related Experiment Videos

Early onset neonatal sepsis.

Betty Chacko1, Inderpreet Sohi

  • 1Neonatology Unit, Department of Pediatrics, Christian Medical College & Hospital, Ludhiana, Punjab, India. bettychacko@hotmail.com

Indian Journal of Pediatrics
|February 3, 2005
PubMed
Summary

Maternal risk factors significantly predict early onset sepsis (EOS) in neonates, even those with prematurity or low birth weight. Screening asymptomatic infants is only necessary if maternal risk factors are present.

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Area of Science:

  • Neonatal Medicine
  • Infectious Diseases
  • Perinatology

Background:

  • Early onset sepsis (EOS) is a significant cause of neonatal morbidity and mortality.
  • Identifying reliable risk factors for EOS is crucial for timely intervention.

Purpose of the Study:

  • To investigate maternal risk factors associated with EOS.
  • To describe the clinical and bacteriological characteristics of EOS in a tertiary care setting.

Main Methods:

  • Retrospective analysis of neonatal case records.
  • Diagnosis of EOS based on clinical signs within 72 hours or positive blood/CSF cultures with maternal risk factors.
  • Statistical analysis using Odds Ratio, Chi-square, and Fisher's exact tests.

Main Results:

  • EOS incidence was 20.7 per 1000 live births, comprising 55.4% of overall sepsis.
  • Significant EOS risk factors included prolonged rupture of membranes, foul liquor, midwife handling, and maternal UTI (p < 0.05).
  • Culture-proven EOS showed Pseudomonas as the most common isolate (60%); case fatality rate was 19.4%.

Conclusions:

  • Maternal risk factors are key indicators for EOS screening, even in high-risk neonates (preterm, LBW, asphyxiated).
  • Targeted screening based on maternal factors can optimize resource allocation.
  • Understanding causative organisms aids in prompt, effective treatment to reduce neonatal mortality.

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