Related Experiment Video
Updated: Aug 19, 2026

Fabrication and Implantation of Miniature Dual-element Strain Gages for Measuring In Vivo Gastrointestinal Contractions in Rodents.
Published on: September 18, 2014
Effect of humulus lupulus on gastric secretion in a rat pylorus-ligated model
Takashi Kurasawa1, Yuichi Chikaraishi, Akira Naito
1Sagami Research Laboratory, Wakamoto Pharmaceutical Co., Ltd, 378 Kanade, Ohi-machi, Ashigarakamigun, Kanagawa 258-0018, Japan. t.kura@wakamoto-pharm.co.jp
Abstract:
In this study, we investigated the pharmacological effect of humulus lupulus (hops) on gastric juice volume and acidity using a rat pylorus-ligated model. In an intraorally administered experiment, hops clearly increased gastric juice volume without affecting acidity. On the other hand, hops had no influence on gastric juice volume when it was intragastrically administered. A cholinergic agonist, carbachol, increased gastric juice volume without affecting acidity, whereas histamine increased gastric juice volume and acidity. The increase of gastric juice volume induced by carbachol was completely inhibited by atropine. On the other hand, atropine did not inhibit the increase in gastric juice volume induced by histamine. The increase in gastric juice volume induced by hops was completely inhibited by atropine. These results suggested that the increase in gastric juice volume induced by intraorally administered hops could be mediated by the cholinergic nervous system.
More Related Videos
Related Concept Videos
Pathophysiology of Peptic Ulcer Disease: Injurious Factors
In the antrum region, G cells secrete the gastrin hormone that binds to gastrin-cholecystokinin-B (CCK2) receptors on parietal and enterochromaffin-like (ECL) cells in the fundic glands. Simultaneously, the vagus nerve releases acetylcholine, which binds to M3...
Pathophysiology of Peptic Ulcer Disease: Mucosal Defense Factors
Hormonal Regulation
Gastritis II: Pathophysiology
Peptic Ulcer Disease II: Pathophysiology
Intestinal Phase of Digestion
The arrival of the chyme in the small intestine distends the duodenum, which triggers the enterogastric reflex. This distension...
