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ent-pimarane-type diterpenoids from Siegesbeckia orientalis L
Phan Minh Giang1, Phan Tong Son, Hideaki Otsuka
1Faculty of Chemistry, College of Natural Science, Vietnam National University, Hanoi, Vietnam.
Chemical & Pharmaceutical Bulletin
|February 3, 2005
Summary
A novel ent-pimarane glucoside, hythiemoside B, was identified in Siegesbeckia orientalis. This study details its isolation, structure elucidation, and characterization alongside known compounds.
Area of Science:
- Natural Product Chemistry
- Phytochemistry
- Organic Chemistry
Background:
- Siegesbeckia orientalis (Asteraceae) is a plant source of bioactive compounds.
- Ent-pimarane diterpenoids are a class of natural products with diverse biological activities.
Purpose of the Study:
- To isolate and characterize new and known compounds from Siegesbeckia orientalis.
- To elucidate the structure of a novel ent-pimarane glucoside.
Main Methods:
- Isolation of compounds using chromatographic techniques.
- Structure elucidation via spectroscopic analyses (NMR, 2D NMR) and chemical transformation.
- Compilation of NMR data for known compounds.
Main Results:
- A new ent-pimarane glucoside, hythiemoside B (4), was isolated.
- Four known ent-pimarane-type diterpenoids (1-3, 5) were co-isolated.
- The structure of hythiemoside B was determined through comprehensive spectroscopic analysis.
- NMR data for compounds 1 and 5 were documented.
Conclusions:
- Hythiemoside B is a newly identified natural product from Siegesbeckia orientalis.
- The study expands the knowledge of ent-pimarane diterpenoids in this plant species.
- Detailed structural information and NMR data were provided for the identified compounds.